Job Details

  • Title: Scientist (Cell Culture)
  • Code: RCI-18984
  • Location: South San Francisco, CA 94080
  • Posted Date: 08/05/2022
  • Duration: 6 Months
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  Job Description

Description Details

Transporter Scientist-II Contractor (DMPK-BA) 

  • The DMPK-BA department in Client Bay Area (ABA), CA is seeking a highly motivated Transporter Scientist contractor (6 months) to join the In Vitro ADME group (Uptake Transporter Center of Excellence).
  • The successful candidate will work in collaboration with other team members to characterize the ADME properties of candidate drug molecules.
  • DMPK-BA works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
  • In this role, you will be a scientist with hands-on experience for routinely managing mammalian cells, heaptocytes-based drug transporter assays to characterize pipeline candidate in a state-of-the art facility.

Key Accountabilities/Core Job Responsibilities:

  • Routine mammalian cell culture and preservation in an efficient manner
  • Handling and seeding of primary hepatocytes and recombinant cells
  • Conducting HT-screening for inhibition potential on uptake transporters
  • Conducting in vitro ADME studies
  • Analyzing data and maintenance of detailed, accurate and comprehensible study documentations
Are you open to look at candidates willing to relocate? Yes

Years of experience/education and/or certifications required: 

  • PhD/PharmD degree (0-2 years of experience), MS degree (+4 years of experience), B.S. (6 years of experience) in pharmacy, pharmacology, pharmaceutical sciences, biological chemistry or equivalent in drug metabolism or related discipline with relevant industry experience in drug discovery/development

What are the top 3-5 skillsrequirements should this person have?

  • Excellent skills and understanding of recombinant/transiently transfected cell lines, culture, seeding, storage is must
  • Working experience with hepatocytes, 2D/3D culture
  • Hands-on-experience with molecular and cellular biology laboratory techniques 

What is a nice to have (but not required) regarding skills, requirements, experience, education, or certification? 

  • Working experience with in vitro drug transporters, metabolism is a plus
  • Familiarity with enzyme/transporter kinetics, data fitting
  • Experience with radioisotope is a plus
  • Knowledge of both biological and physicochemical properties of small molecules that influence ADME
  • Experience with use of electronic lab notebook is a plus
  • The individual is also expected to be organized, a team player, passionate about drug discovery, and possess effective communication skills 

What type of environment is this person working in?

  • Group setting
  • Individual Setting
  • XXX Combination of both
  • Work ScheduleMonday to Friday- Reg hours 

Does this position offer the ability to work remotely on a regular basis or is it an on-site role?100% onsite

Is the worker onshore or offshore? No

Will there be Domestic and/or International Travel? No